ABSTRACT
Objective: To investigate the chemical constituents from the water extract of Rhodiola wallichiana. Methods: The chemical constituents were isolated by repeated dynamic axial compression chromatography, Sephadex LH-20 column chromatography, and prep-HPLC, and their structures were identified by the basis of spectral data analysis. Results: Eleven compounds were isolated from the water extract and identified to be gallic acid (1), syringic acid (2), tyrosol (3), salidroside (4), 3,4- dihydroxybenzoic acid (5), 4-hydroxybenzoic acid (6), 4-hydroxyphenylacetic acid (7), p-coumaric acid (8), p-coumaric acid-4-O-β-D- glucopyranoside (9), benzyl-O-β-D-glucopyranodide (10), piceoside (11), dihydroconiferin (12), bergeninum (13), rhodiocyanoside A (14), and 5-hydroxymethylfurfural (15). Conclusion: Compounds 7 and 15 are isolated from the plants of Rhodiola L. for the first time, and compounds 5-6, 8-12, and 14 are obtained from R. wallichiana for the first time.